Today: 27.05.2018
News
Opinion
Business
Living
Metro
Tech
Sport

Last News

16:56
Today
16:36
Today
14:38
Today
13:05
Today
12:36
Today
11:49
Today
11:06
Today
10:56
Today
10:25
Today
09:54
Today
08:16
Today
00:13
Today
22:18
26.05.2018
18:27
26.05.2018
17:09
26.05.2018
15:55
26.05.2018
15:06
26.05.2018
15:02
26.05.2018
14:24
26.05.2018
10:27
26.05.2018
09:40
26.05.2018
09:08
26.05.2018
07:59
26.05.2018
07:43
26.05.2018
01:53
26.05.2018
01:40
26.05.2018
01:07
26.05.2018
00:47
26.05.2018
20:00
25.05.2018
18:30
25.05.2018

Man ‘cured’ of HIV through gene editing holds hope for others.

For more than a decade, the strongest AIDS drugs could not fully control Matt Chappell’s HIV infection. Now his body controls it by itself, and researchers are trying to perfect the gene editing that made this possible. Scientists removed some of his blood cells, disabled a gene to help them resist HIV, and returned these...
Time: 12:56     Date: 13.02.2018
US Living News: Man ‘cured’ of HIV through gene editing holds hope for others. NY Post 24 - US News

Scientists removed some of his blood cells, disabled a gene to help them resist HIV, and returned these “edited” cells to him in 2014. So far, it has given the San Francisco man the next best thing to a cure.

“I’ve been off medications for three and a half years,” he said. He even was able to keep the virus in check despite cancer treatments last year that taxed his immune system.

Chappell was lucky, though. Only a few of the 100 others in those experiments were able to stay off HIV drugs for a couple years; the rest still need medicines to keep HIV suppressed.

Now researchers think they can improve the treatment and are trying again to tackle HIV by doctoring DNA. New studies to test these tweaked approaches in people are getting underway.

“Gene therapy techniques have advanced greatly,” said Dr. Otto Yang of the UCLA AIDS Institute, one place working on this. “A lot of people are thinking it’s the right time to go back.”

They include Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, which is funding some of the new studies. He doesn’t think the technique will become common because millions of people do well on existing treatments. But he says it could help those who can’t easily control the virus, and should be pursued because it holds potential for a cure.

“They’re very bold, innovative techniques, mostly to try and cure people,” he said. “It’s worth trying because the science is there.”

One man’s cure gave hope Matt Chappell’s HIV infection has effectively been cured.AP

Only one person is known to have been cured of HIV infection, a man who had a cell transplant a decade ago from a donor with natural immunity to the virus. The donor lacked a common gene that makes an entryway HIV uses to infect T cells, immune system soldiers in the blood.

The transplant gave the recipient that protection, but procedures like that are too risky and impractical for wide use. Scientists have been trying to find a way to create similar immunity by altering some of a patient’s own cells. They use a gene editing tool called zinc finger nucleases, which cut DNA at a precise spot to disable the HIV entryway gene.

The California company that makes the editing tool, Sangamo Therapeutics, sponsored the initial studies.

“It worked, the T cells were edited,” said Sangamo’s president, Dr. Sandy Macrae. But it didn’t work quite well enough: The altered T cells were outnumbered by T cells that were not altered and could still be infected.

Now, Dr. John Zaia at City of Hope, a research center in Duarte, California, is trying the approach with a twist. He’s using blood stem cells – parent cells that produce many others. Once a stem cell is altered the benefit should multiply and last longer, Zaia said.

The silver lining Chappell is one of the few patients who could stop taking their HIV drugs after the gene-editing treatment.AP

Though the initial gene editing experiments were disappointing, there was a silver lining. Patients in those studies had a big drop in the number of cells where HIV lurked in a dormant state – the so-called reservoir of silent disease.

At Case Western Reserve University in Cleveland, Dr. Rafick-Pierre Sekaly is trying to capitalize on that drop. His study will try the same gene editing – disabling the gene that makes the HIV entryway – while keeping patients on strong antiviral medicines for at least a year before discontinuing them.

“As long as we’re not able to get rid of this reservoir, we’ll never be able to stop treatment,” he explained.

The hope is that the medicines plus the altered cells will knock down the virus and reduce the reservoir to a point where the body can control any residual disease by itself, as Chappell seems to be doing.

Protect and attack James RileyAP

University of Pennsylvania scientists are trying a two-part approach: Besides knocking out the gene for the HIV entryway, they’re adding a gene to help T cells recognize and kill HIV. This second part is called CAR-T therapy, a treatment approved last year for treating cancer.

The new study’s leader, scientist James Riley, is encouraged that some patients at Penn who were in the early studies kept HIV suppressed for nearly a year without drugs.

“You’d never know they were sick” even though the virus could still be detected, Riley said. “At some point you’re going to have confidence that it’s not going to come back.”

Chappell’s doctor, Christopher Schiessl at One Medical, a health clinic in San Francisco, hopes that’s the case for Chappell. Although he’s doing well now, Chappell is showing signs that his immune system may be weakening, Schiessl said.

Chappell is optimistic, and believes gene therapy ultimately will provide a long-term solution.

“If we’re going to cure HIV,” he said, “this is how it’s going to happen.”

Living

US Living News: Someone is actually making an ‘active shooter’ video game. NY Post 24 - US News
Someone is actually making an ‘active shooter’ video game.
“Active Shooter,” a video game that allows players to simulate a school shooting, prompted outrage in the wake...
US Living News: More than 228K pounds of Spam recalled. NY Post 24 - US News
More than 228K pounds of Spam recalled.
AUSTIN, Minn. — The U.S. Department of Agriculture is recalling more than 228,000 pounds of Spam and another product made...
US Living News: Why is it so hard to leave a job you hate?. NY Post 24 - US News
Why is it so hard to leave a job you hate?.
I honestly cannot be any clearer: I absolutely hate my job. I hate everyone I work with. I dread getting up in the mornings...
US Living News: Congrats, class of 2018: How to land a job, when you’re ready. NY Post 24 - US News
Congrats, class of 2018: How to land a job, when you’re ready.
You know what they say about the early bird catching the worm? Something similar holds true for new college graduates and...

Opinion

Last US News - Opinion: Obama’s spying scandal is starting to look a lot like Watergate. NY Post 24 - US News
Obama’s spying scandal is starting to look a lot like Watergate.
“F.B.I. Used Informant to Investigate Russia Ties to Campaign, Not to Spy, as Trump Claims,” read the headline...
Last US News - Opinion: Conservatives need to argue over ideas, not Trump. NY Post 24 - US News
Conservatives need to argue over ideas, not Trump.
“Let’s grow up, conservatives.” That call to arms was delivered by Barry Goldwater at the 1960 Republican convention...
Last US News - Opinion: A President Clinton would have made things much worse. NY Post 24 - US News
A President Clinton would have made things much worse.
To put the roller-coaster presidency of Donald Trump in perspective, it helps on occasion to imagine that Hillary Clinton...
Last US News - Opinion: Mario Cuomo’s lesson for Bill de Blasio. NY Post 24 - US News
Mario Cuomo’s lesson for Bill de Blasio.
It’s no secret that Mayor de Blasio hates the New York Post with a passion that is pretty much all-consuming. OK, so he...
Last US News - Opinion: What’s really blocking opportunity in NYC schools. NY Post 24 - US News
What’s really blocking opportunity in NYC schools.
New schools Chancellor Richard Carranza had quite the week, first signaling his desire to dump the single-test admissions...

Living

US Living News: Someone is actually making an ‘active shooter’ video game. NY Post 24 - US News
Someone is actually making an ‘active shooter’ video game.
“Active Shooter,” a video game that allows players to simulate a school shooting, prompted outrage in the wake...
US Living News: More than 228K pounds of Spam recalled. NY Post 24 - US News
More than 228K pounds of Spam recalled.
AUSTIN, Minn. — The U.S. Department of Agriculture is recalling more than 228,000 pounds of Spam and another product made...
US Living News: Why is it so hard to leave a job you hate?. NY Post 24 - US News
Why is it so hard to leave a job you hate?.
I honestly cannot be any clearer: I absolutely hate my job. I hate everyone I work with. I dread getting up in the mornings...
US Living News: Congrats, class of 2018: How to land a job, when you’re ready. NY Post 24 - US News
Congrats, class of 2018: How to land a job, when you’re ready.
You know what they say about the early bird catching the worm? Something similar holds true for new college graduates and...
US Living News: I accidentally threw away $60M worth of Bitcoin. NY Post 24 - US News
I accidentally threw away $60M worth of Bitcoin.
After Matthew Mellon, scion of the Mellon banking fortune, died on April 16 of a drug-related heart attack in Mexico, his...
US Living News: PC police won’t let us use these words anymore. NY Post 24 - US News
PC police won’t let us use these words anymore.
On a crowded elevator in San Francisco in April, Richard Ned Lebow was asked what floor he wanted. The 76-year-old professor...
US Living News: Why GPS will never make the road atlas obsolete. NY Post 24 - US News
Why GPS will never make the road atlas obsolete.
Peter Dalbis has been alive for 76 years, and at least 50 of those were spent following directions in Rand McNally road atlases....
US Living News: Deadbeat son is a sign of America’s failure to raise boys. NY Post 24 - US News
Deadbeat son is a sign of America’s failure to raise boys.
Last week, a judge in New York ruled that a 30-year-old man must move out of his childhood home on June 1 after his parents...

Business

Last US Business News: Reed Hastings and the Obamas are making bank with Netflix deal. NY Post 24 - US News
Reed Hastings and the Obamas are making bank with Netflix deal.
Reed Hastings, the founder, chairman and CEO of Netflix, had quite a run last week. The darling of streaming saw his company...
Last US Business News: Credit card rewards may stop existing soon. NY Post 24 - US News
Credit card rewards may stop existing soon.
The days of credit card users getting just about anything and everything in rewards are over, as issuers gird for choppy...
Last US Business News: Casual attire can hurt business productivity: book. NY Post 24 - US News
Casual attire can hurt business productivity: book.
As Memorial Day weekend marks the unofficial beginning of summer, many offices now will allow casual attire on more than...
Last US Business News: Readers sick of dealing with neighbor from hell. NY Post 24 - US News
Readers sick of dealing with neighbor from hell.
Dear John: I’ve been reading about things you’ve done in the past. Maybe you could help me with a serious situation soon....
Last US Business News: Tax refunds aren’t enough to improve the economy. NY Post 24 - US News
Tax refunds aren’t enough to improve the economy.
Dear John: Mick Mulvaney, head of the Office of Management and Budget, is being optimistic about the future growth of the...
Last US Business News: Blade isn’t leaving East Hampton after all. NY Post 24 - US News
Blade isn’t leaving East Hampton after all.
Blade — the Uber-like helicopter service to the East End — had to endure blaring headlines this spring that it lost its...
Last US Business News: Ex-Xerox CEO caves to pressure, gives up $18M golden parachute. NY Post 24 - US News
Ex-Xerox CEO caves to pressure, gives up $18M golden parachute.
Xerox’s former boss gave up an $18 million golden parachute this month as he caved to pressure from billionaire Carl Icahn,...
Last US Business News: Trump administration reaches deal to save Chinese giant ZTE. NY Post 24 - US News
Trump administration reaches deal to save Chinese giant ZTE.
The Trump administration has told Congress that it’s reached a deal on Friday that would allow Chinese telecommunications...

Metro

Metro News: Whale carcass washes ashore on Fire Island beach. NY Post 24 - US News
Whale carcass washes ashore on Fire Island beach.
A whale carcass washed up on the beach in Fire Island Sunday morning, photos posted online show. Images posted to Instagram...
Metro News: Harlem man dies in police custody: NYPD. NY Post 24 - US News
Harlem man dies in police custody: NYPD.
An emotionally disturbed man died while in police and EMS custody early Sunday morning, authorities said. The 39-year-old’s...
Metro News: Woman struck by alleged drunk driver in Montauk. NY Post 24 - US News
Woman struck by alleged drunk driver in Montauk.
A Manhattan woman was struck by a drunk driver in Montauk over Memorial Day weekend, according to a report. The 26-year-old...
Metro News: Owner’s excuse for leaving dogs in hot car: I was drunk. NY Post 24 - US News
Owner’s excuse for leaving dogs in hot car: I was drunk.
The Staten Island man who left his two dogs trapped inside a stifling hot car in Brooklyn allegedly told police he was drunk...
Metro News: Karate instructor busted for sexually abusing girls. NY Post 24 - US News
Karate instructor busted for sexually abusing girls.
A Manhattan karate instructor was busted for sexually abusing — and photographing — five young girls in his Inwood...
Metro News: Woman shot while leaving Brooklyn nightclub: cops. NY Post 24 - US News
Woman shot while leaving Brooklyn nightclub: cops.
A woman was shot twice leaving a Brooklyn nightclub early Sunday morning, police said. The 32-year-old was leaving El Gran...
Metro News: School behind silent tribute for Gaza victims gets death threat. NY Post 24 - US News
School behind silent tribute for Gaza victims gets death threat.
A moment of silence at the Beacon School for those killed in Gaza continues to reverberate. William Stroud, the assistant...
Metro News: NYPD rescues kayakers stranded in Jamaica Bay. NY Post 24 - US News
NYPD rescues kayakers stranded in Jamaica Bay.
In a dramatic rescue, cops used an NYPD helicopter to scoop up two people who had tipped out of their kayaks in Jamaica Bay...

Sport

Last US Sport News: Mets bullpen implodes in latest disaster. NY Post 24 - US News
Mets bullpen implodes in latest disaster.
MILWAUKEE — Robert Gsellman has been among the Mets’ most reliable bullpen options this season, and Jerry Blevins not...
Last US Sport News: Masahiro Tanaka bounces back in dominant win over Angels. NY Post 24 - US News
Masahiro Tanaka bounces back in dominant win over Angels.
The Yankees had lost three of four heading into Sunday and face the unenviable task of hosting the Astros this week, who...
Last US Sport News: Mickey Callaway has backed up his talk but now must build on it. NY Post 24 - US News
Mickey Callaway has backed up his talk but now must build on it.
Just forty-nine games into his professional managerial career, Mickey Callaway has re-taught us two valuable lessons: 1)...
Last US Sport News: Danica Patrick crashes out of Indy 500 in final race of career. NY Post 24 - US News
Danica Patrick crashes out of Indy 500 in final race of career.
Danica Patrick’s racing career has ended with a crash in Turn 2 of the Indianapolis 500. Patrick lost control of the...
Last US Sport News: Venus Williams flames out in first round of French Open. NY Post 24 - US News
Venus Williams flames out in first round of French Open.
Venus Williams is out of the French Open on opening day. The 2002 runner-up and ninth-seeded American lost 6-4, 7-5 to Wang...